Our NAD Replenish infusion comes in 250mg or 500mg doses; NAD+ is a coenzyme every cell uses to turn food into energy, and the drip runs slowly and is checked throughout for comfort. Doctor-led, with a consultation first to agree your dose and timing, at our CQC-registered clinic near Piccadilly in Manchester. From £275.
CQC registered · Doctor-led clinic · Consultation first · 250mg and 500mg doses · Whitworth Street, Manchester · Q-Park parking
Who it’s for
Before you book NAD+ IV in Manchester, we talk through your goals and health history.
Longevity-focused routine
Some people add NAD+ to a wider wellness plan. So your clinician checks whether an infusion fits that plan.
Cellular energy
Every cell in your body uses NAD+, a coenzyme. It also plays a part in how cells turn food into energy.
Dose choice at consultation
You and your clinician choose between 250mg and 500mg. Because the drip runs slowly, the larger dose means a longer visit.
Prefer a shorter visit?
IM NAD+ injections (50mg and 100mg) take about 10 minutes. They differ from a drip, so ask us which option suits you.
Every first visit starts with a consultation before any treatment. During it, our clinician reviews your medical history, medicines and goals. After that, you agree a dose together.
During your consultation, we ask about heart, kidney and liver conditions, plus any medicines you take. If a concern comes up, your clinician may advise against treatment. Where tests help, we can arrange blood testing first.
Generally, NAD+ runs slowly for comfort. That is why 250mg takes about two hours and 500mg about four. Meanwhile, the team checks on you and can slow the drip if you feel uncomfortable.
Single session, about 2 hours. Courses also available: 6× £1,485 · 10× £2,330
Single session, about 4 hours. Courses also available: 6× £2,295 · 10× £3,600
Prices as shown on our booking page. Course options also appear on Fresha where available. Book any treatment online, or call 0161 566 5099.
Prefer a different drip? Alongside high-dose NAD+ IV, our IV vitamin therapy menu includes these doctor-led drips and intramuscular shots. Prices as shown on our booking page.
| Treatment | Type | Price | Time | Book |
|---|---|---|---|---|
| Vitamin C — Skin & Immunity | IV | from £145 (7.5g–50g) | ~60 min | Book vitamin C IV |
| Myers’ — Total Hydration | IV | £225 | ~60 min | Book Myers’ |
| Glutathione — Detox & Glow | IV | 600mg £120 · 1200mg £150 | ~60 min | Book glutathione |
| IV Anti-Aging Drip | IV | £225 | ~60 min | Book Anti-Aging Drip |
| IM Vitamin B12 Injection | IM | £40 | ~10 min | Book B12 |
| IM NAD+ Injection 50mg | IM | £50 | ~10 min | Book IM NAD+ 50mg |
| IM NAD+ Injection 100mg | IM | £75 | ~10 min | Book IM NAD+ 100mg |
You can also read about our doctor-led IV drips, what an IV drip costs and how to prepare for a blood test.
How it works
Come to 14–16 Whitworth Street, near Piccadilly. If you drive, Piccadilly Q-Park sits directly above the clinic, so parking is easy.
First, your clinician reviews your health and medicines. Then, together, you choose 250mg or 500mg and decide whether to go ahead.
Because the drip runs slowly, it takes about two hours for 250mg and about four hours for 500mg. So, bring a laptop, a book or headphones.
Afterwards, the team removes the cannula and gives you aftercare advice. Then most people head straight back to their day.
The detail
NAD+ stands for nicotinamide adenine dinucleotide. Your body also makes it from vitamin B3 (niacin) and other building blocks. If you want background reading, the NHS has a general guide to B vitamins and folic acid.
Unlike most vitamin drips, NAD+ runs slowly for comfort. As a result, a 250mg session takes about two hours. Meanwhile, the 500mg dose takes about four hours.
NAD Replenish is the most intensive drip on our IV menu. When you book NAD+ IV in Manchester with us, you choose 250mg or 500mg. Your clinician recommends a starting point, and then you can review it at later visits.
Everyone responds differently, so individual results vary. For that reason, we do not promise specific outcomes. Instead, we focus on a safe, comfortable infusion and clear advice.
Clinical governance
Dr Callum Shields
MBChB, LLM, MPhil, MRCS (ENT) · Medical Director, Thriyv
Dr Shields oversees every IV protocol at Thriyv, including this one. Our clinic holds CQC registration for diagnostic and screening procedures, and you can look up any provider on the CQC website. Also, our team follows written protocols for consultation, infusion rate and aftercare.
Who this is not for. This is a wellbeing service rather than urgent or emergency care. So if you have urgent symptoms, contact your GP or NHS 111. Also, in an emergency, call 999.
FAQ
It is our doctor-led NAD Replenish infusion. You can choose a 250mg or 500mg dose, and your clinician agrees the right dose with you after a consultation.
Visit Thriyv at 14–16 Whitworth Street, Manchester M1 3BS, about a five-minute walk from Piccadilly station. If you drive, Piccadilly Q-Park sits above the clinic.
A single 250mg session costs £275, while a 500mg session costs £425. Course prices also appear in the pricing section above, and you can book each dose online through Fresha.
The 250mg drip takes about two hours, while the 500mg drip takes about four hours. Also, allow extra time for your consultation.
Yes. Every client has a doctor-led consultation before treatment, so your clinician can check suitability and agree a dose.
People with certain heart, kidney or liver conditions may not be suitable. Pregnancy and some medicines can also rule it out, so your clinician will advise at consultation.
No. IM NAD+ injections (50mg for £50, 100mg for £75) go into a muscle and take about 10 minutes. By contrast, NAD Replenish is an intravenous drip.
When you are ready, use any Book button on this page to choose your dose on Fresha. Alternatively, call 0161 566 5099 or message us on WhatsApp.
Yes. Piccadilly Q-Park sits directly above the clinic at 14–16 Whitworth Street, so parking is simple.
Thriyv is at 14–16 Whitworth Street, Manchester M1 3BS, near Piccadilly. Our clinic also holds CQC registration for diagnostic and screening procedures.
Thriyv sits at 14–16 Whitworth Street, Manchester M1 3BS, in the city centre. So the clinic is about a five-minute walk from Manchester Piccadilly station. It is also handy if you live or work in the Northern Quarter, Deansgate or Salford.
Parking: Piccadilly Q-Park sits directly above the clinic building, so parking is simple when you drive in.
If you have a question before you visit, call 0161 566 5099 or email info@thriyv.co.uk.
We get it. Sometimes you want to learn a bit more before you book.
If you have a question about high-dose NAD+ IV, drop us a line using the form. Then one of the Thriyv team will reply as soon as possible.
Please note: our replies sometimes land in spam, so please save info@thriyv.co.uk to your contacts.
When you are ready, book your high-dose NAD+ IV consultation in Manchester.
Choose your dose online, or call 0161 566 5099 if you would rather talk first. You can also explore all Thriyv services.
Medically reviewed by Dr Callum Shields, Medical Director · Last reviewed 6 October 2026
