Thriyv’s Polynucleotide Treatments offer a powerful new way to restore your skin – without changing who you are. Backed by decades of research and designed to stimulate your skin’s natural repair systems, polynucleotides go far beyond surface-level results.
Unlike dermal fillers that simply add volume, polynucleotides help your skin heal and regenerate from within. They activate your fibroblast cells – essential for collagen, elastin, and hydration – giving you firmer, healthier, more radiant skin that’s truly yours.
If you are a new client, we strongly recommend booking one of our consultation services to ensure your treatment plan aligns perfectly with your goals and concerns.
If you’ve already completed your consultation and are ready to proceed with treatment, click the button below to visit our booking page.
Sometimes skincare stops working the way it used to. You’re eating well, using good products, and doing all the right things – but the skin just isn’t responding like it used to. That’s where polynucleotides come in! Unsure whether Polynucleotides are for you? Check out some of the concerns Polynucleotides can help with:
Polynucleotides don’t mask problems – they help your skin work better. The result? A gradual, natural improvement in how your skin looks, feels, and functions.
Every aesthetics treatment at Thriyv begins with a comprehensive consultation. On your arrival at our Manchester City Centre wellness hub, one of our medical professionals will review your medical history, discuss your aesthetics goals and how Thriyv can help you achieve them. If all is well, and depending on your timescales, your treatment will go ahead the same day or be scheduled for a later date of your choosing.
As part of our commitment to client safety, our medical professionals may deem you unsuitable to progress with your intended treatment. Depending on the circumstances, your treatment may be deferred to a later date or postponed indefinitely. Regardless, your medical practitioner will fully inform you as to why and what alternatives may be available to you in the meantime.
For further details of our treatment booking & refund policies, please see here.
Your treatment will be delivered in one of our clean, professional and purpose built aesthetics treatment rooms. Your comfort and safety is paramount. That’s why all of our aesthetic treatments are delivered by medical professionals with an excellent understanding of facial anatomy.
We also use premium, comfortable treatment beds, high strength numbing cream and top quality needles to help you relax and minimise discomfort whilst you undergo your transformation.
On completion of your treatment, you’ll be provided with thorough aftercare guidance including tips and tricks on how to minimise swelling. The downtime post-Polynucleotides Treatment is typically minimal, however this varies from person-to-person.
To aid with recovery and ensure your Polynucleotides settle, it’s recommended you avoid the following during the first 24 hours as a minimum:
Completed your Polynucleotides transformation and looking for ways to keep your skin looking youthful for longer? Interested in taking your self-care and wellbeing to the next level?
Thriyv offers a suite of wellness, aesthetics and skincare services meaning you can continue your journey with us and feel rejuvenated both inside and out!
For new clients, your first appointment takes approximately 1 hour — including a medical consultation, facial assessment, and discussion of treatment areas with Dr Callum Shields (MBChB). For returning clients, follow-up treatments take approximately 30 minutes. We never compress the first appointment — proper assessment is what separates a clinical aesthetic result from a salon experience.
Polynucleotide treatments at our Manchester clinic are £300 per area — substantially less than London clinic pricing (£350–£500 per area) for clinically equivalent treatment. A course of 3 sessions, spaced 3–4 weeks apart, is typically recommended for optimal results. Course pricing is available here.
Polynucleotides are highly purified DNA fragments that, when injected into the skin, trigger your body’s own regeneration response. Unlike dermal filler — which adds volume by sitting in the tissue — polynucleotides work at a cellular level, prompting your skin to rebuild itself.
The clinical effects include:
Polynucleotides are classed as a bio-regenerator, not a filler — they don’t change the shape of your face, they regenerate the quality of your skin.
Yes — and it’s clinically safer than it sounds. The polynucleotides used in modern aesthetic medicine are purified DNA fragments extracted from salmon or trout sperm cells. Salmon DNA is used because it has the closest molecular structure to human DNA, with no immune reaction or rejection risk.
The DNA is:
Polynucleotides have over 30 years of clinical use — originally developed in Italy in the 1990s for wound healing and orthopaedic regeneration. The aesthetic application is more recent but built on a long safety record.
Polynucleotides are most commonly used at Thriyv for:
Dr Cal will assess your skin at consultation and recommend the right treatment areas and course length for your specific concerns.
Polynucleotides build results gradually — this isn’t an instant treatment:
Unlike filler, you won’t see a “before and after” overnight. The clinical advantage is that results look natural and gradual — friends will say you look well, not that you look done.
A full course of 3 treatments typically delivers visible results for 6–12 months. Maintenance treatments every 6–9 months preserve and build on results long-term. Many clients fold maintenance treatments into a wider skin protocol alongside microneedling, polynucleotides for the under-eye, and red light therapy.
Mild discomfort is normal but well-managed. We apply medical-grade numbing cream to the treatment area before injection, and the polynucleotide product itself contains an anaesthetic component in some formulations. Most clients describe the sensation as brief pinpricks — the under-eye area is the most sensitive, the cheeks and face less so.
Post-treatment: mild tenderness for 24 hours is normal. We provide full written aftercare.
Minimal but real. Expect:
Most clients schedule treatments Thursday or Friday to allow the weekend for recovery. Avoid the gym, alcohol, saunas, and direct sun for 48 hours post-treatment.
Thriyv uses UK-licensed, medical-grade polynucleotide products only — including market-leading brands such as Ameela, Plinest, and PhilArt. These are the polynucleotides used in published clinical trials and licensed UK aesthetic practice.
Why this matters: under upcoming 2026 DHSC licensing rules, unbranded or grey-market polynucleotides will be illegal to inject in the UK. Many Manchester salons currently inject unlicensed or unbranded versions sourced cheaply online. As a doctor-led clinic, Thriyv only ever uses licensed products with full traceability — already operating to the standard the law is moving toward.
Yes — and they’re one of the most effectively stackable treatments in modern aesthetic medicine. Common combinations at Thriyv:
Dr Cal designs combination protocols based on your skin and goals — not a one-size product menu.
Polynucleotides have one of the strongest safety profiles in modern aesthetics — over 30 years of clinical use, no protein content, no allergy risk, no immune rejection. Contraindications include pregnancy, breastfeeding, active autoimmune conditions, active infection at the treatment site, and known fish allergies (extremely rare given the purification process, but screened for at consultation).
Every new client is medically assessed by Dr Callum Shields (MBChB) before treatment. Under 2026 DHSC licensing reforms, polynucleotide injection will be restricted to licensed medical professionals — Thriyv already operates at this clinical standard.
Most healthy adults aged 25+ are suitable candidates. Polynucleotides are particularly effective for:
Polynucleotides are not suitable for clients seeking immediate visible change, significant volume restoration, or facial reshaping — for those goals, dermal filler or surgical referral may be more appropriate.
We’re at 14–16 Whitworth Street, Manchester, M1 3BS — in the heart of Manchester city centre, ideally located between Piccadilly Station and Oxford Road Station. Our Wellness & Aesthetics Hub combines polynucleotide treatments with microneedling, Sunekos, skin boosters, red light therapy, and the wider clinical aesthetics menu — all under medical supervision.
Thriyv Wellness & Aesthetics is located in the heart of Manchester City Centre, right between Manchester Piccadilly Train Station and Kampus.
We’re just a few moments walk from major rail, tram and bus hubs, with a multi-story carpark next door. This means its never been easier to start your journey at Thriyv, whether you’re based in Manchester City Centre or travelling from further afield.
Our full address is Thriyv, 14-16 Whitworth Street, Manchester, M1 3BS. See you soon!
Ready to take control of your aesthetic and wellness journey?
Thriyv, and our medical professionals, are ready and waiting to support you in reaching your goals.
To begin, book your next service/treatment below!
We get it. Sometimes you want to learn a bit more about a service without the hassle of an in-clinic consultation.
If you’d like to learn more about our Polynucleotides service, or how Thriyv’s unified and complimentary services can help you achieve your goals, drop us a line via the form below. One of the Thriyv team will be back in touch with you as soon as possible!
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